The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design
نویسندگان
چکیده
منابع مشابه
The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.
Group A Streptococcus (GAS) is a leading cause of infection-related mortality in humans. All GAS serotypes express the Lancefield group A carbohydrate (GAC), comprising a polyrhamnose backbone with an immunodominant N-acetylglucosamine (GlcNAc) side chain, which is the basis of rapid diagnostic tests. No biological function has been attributed to this conserved antigen. Here we identify and cha...
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Antigenic determinant of the Lancefield group H antigen of Streptococcus sanguis.
Previous studies indicated that the teichoic acid isolated from strains of Streptococcus sanguis was group specific and defined the Lancefield group H streptococci. To determine the specific antigenic determinants, the antigen was extracted from a group H streptococcus (ATCC 903) by the phenol-water method and purified by column chromatography. The isolated antigen had a glycerol/phosphate/gluc...
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Blood group antigen recognition by a Streptococcus pneumoniae virulence factor.
The Streptococcus pneumoniae fucose utilization operon includes a gene encoding a virulence factor that belongs to family 98 in the glycoside hydrolase classification. This protein contains a C-terminal triplet of fucose binding modules that have significant amino acid sequence identity with the Anguilla anguilla fucolectin. Functional studies of these fucose binding modules reveal binding to f...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2014
ISSN: 1931-3128
DOI: 10.1016/j.chom.2014.05.009